This paper will present results from a mixed method study which explored job satisfaction levels of Saudi national nurses working in three main public hospitals of the Makkah Region, of Saudi Arabia. Factors that influence levels of job satisfaction amongst Saudi nurses have been identified. The study design utilised two phases: the first phase distributed a questionnaire with Saudi registered nurses (n = 272) to identify factors that lead to job satisfaction. The second phase of the study consisted of interviews with Saudi nurses (n = 17) and sought a heterogeneous demographic profile. Herzberg’s Motivation-Hygiene Theory has been utilised as the theoretical framework to guide this study. Nurses make up the largest group of health care providers working in a variety of health care systems worldwide (Hassmiller & Cozine, 2006). Saudi Arabia has over many decades relied exclusively on the recruitment of expatriate nurses to service its hospitals. Due to, the global shortage of nurses worldwide, Saudi Arabia is now facing difficulties in recruiting and retaining an expatriate nursing workforce.