Rational Elaborated Common Strategies Employed For The Efficient in Silico Optimization Of An Accesible Synthetically (AMPs) Peptidomimetic-similar To An Amphiphile-Based Pharmacophoric Agent As A Promising Enhanced Therapeutic Antimicrobial Agent

Abstract

Antimicrobial peptides (AMPs) which predominantly act via membrane active mechanisms have
emerged as an exciting class of antimicrobial agents with tremendous potential to overcome the global
epidemic of antibiotics-resistant infections. The first generation of AMPs derived from natural sources as
diverse as plants, insects and humans has provided a wealth of compositional and structural information to
design novel synthetic AMPs with enhanced antimicrobial potencies and selectivities, reduced cost of
production due to shorter sequences and improved stabilities under physiological conditions. As a rational
result we discovered for the first time the GENEA-Antimamphiler-109 utilizing threading/structure-based
BIOGENETOLIGANDOROLTM Rational Strategies employed for the in silico design and optimization of
synthetic antimicrobial peptide mimic amphiphile-based pharmacophoric agents with promising enhanced
therapeutic potentials introducing the iview: an interactive WebGL visualizer for protein-ligand complex
through a subpocket analysis method for fragment-based drug discovery through a KNIME-Shared
BiogenetoligandorolTM binding site amino acid predicted similarity subpockets.